CP-863187

产品名称：

668981-02-0
CP-863187
CP863187
4-(2,5-Difluorophenyl)-5-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxazole
6-[4-(2,5-Difluorophenyl)oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine
6-[4-(2,5-Difluorophenyl)-5-oxazolyl]-3-(1-methylethyl)-1,2,4-triazolo[4,3-a]pyridine

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

CP-863187 is a potent p38α (p38α) inhibitor (IC₅₀ = 5.8 nM) with 44-fold selectivity over p38β (p38β) and no inhibitory potency against p38γ (p38γ) and p38δ (p38δ) isoforms. CP-863187 effectively inhibits LPS-stimulated cellular TNF-α production in vitro (IC₅₀ = 259 and 25 nM, using human whole blood and isolated mononuclear cells, respectively) and in rats in vivo (ED₅₀ = 0.3 mg/kg p.o.) with good pharmacokinetic profile and oral availability (F = 87%/dog, 40%/monkey, 30%/rat with 5 mg/kg oral dosage; F = 66%/rat with 50 mg/kg oral dosage).

法律信息

Sold for research purposes under agreement from Pfizer Inc.

基本信息

经验(实验)分子式	C₁₈H₁₄F₂N₄O
分子量	340.33
MDL编号	MFCD30480740

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	room temp
SMILES string	FC1=C(C2=C(OC=N2)C(C=C3)=CN4C3=NN=C4C(C)C)C=C(F)C=C1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable