产品说明
生化/生理作用
Diquafosol (Up4U, INS365) is a selective purinergic receptor P2Y2 agonist (EC50 = 100 nM/P2Y2, 400 nM/P2Y4, 20 μM/P2Y6, >100 μM/P2Y1 by calcium mobilization using respective 1321N P2Y subtype transfectants). In addition to its in vivo efficacy in anmial dry eye models, diquafosol is also shown to enhance mucociliary clearance in sheep and stimulate vaginal moisture in ovariectomized rabbits.
P2Y2/P2Y4 purinoceptor agonist: EC50 = 0.10 μM at P2Y2, 0.4 μM at P2Y4 (20 μM at P2Y6) in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y1, P2Y2, P2Y4 and P2Y6
诊断含义
In clinical development for the treatment of dry eye and chronic lung disease, such as cystic fibrosis
基本信息
| 经验(实验)分子式 | C18H22N4Na4O23P4 |
| 分子量 | 878.23 |
产品性质
| 质量水平 | 100 |
| 测定 | >95% (HPLC) |
| 形式 | powder |
| 旋光性 | [α]/D -12.0 to -8.0°, c = 1.0 in H2O |
| 颜色 | white to beige |
| 溶解性 | H2O: 2 mg/mL, clear |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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