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EpoY

品牌
Sigma-Aldrich
CAS
245660-13-3
货号
SML2301
规格纯度
≥97% (HPLC)
参考价格
974.06 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
245660-13-3
EpoY
(S)-2-((2S,3S)-3-(ethoxycarbonyl) oxirane -2-carboxamido)-3-(4-hydroxyphenyl) propanoic acid
(2S,3S)-3-[[[(1S)-1-Carboxy-2-(4-hydroxyphenyl)ethyl]amino]carbonyl]-2-oxiranecarboxylic acid 2-ethyl ester
SD-142
产品介绍:

产品说明

生化/生理作用

EpoY is an irreversible inhibitor of the major brain tubulin tyrosine carboxypeptidase (TCP), shown to be a complex of vasohibin-1 (VASH1) with the small vasohibin binding protein (SVBP). Reversible detyrosination of alpha-tubulin is vital to microtubule dynamics and functions including regulation of neuron differentiation, and defects in the detryosination have also been been associated with cancer and cardiomyopathies EpoY inhibited TCP activity with an IC50 value around 500 nM. It reduced detyrosinated a-tubulin levels and caused severe differentiation defects.

基本信息

经验(实验)分子式C15H17NO7
分子量323.30

产品性质

测定≥97% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringO=C(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)[C@H]2O[C@@H]2C(OCC)=O

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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