iHAP1

产品名称：

105925-39-1
iHAP1
(2-Chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)methanone
2-Chloro-10-(4-methoxybenzoyl)-10H-phenothiazine

产品介绍：

产品说明

生化/生理作用

iHAP1 is a potent activator of protein phosphatase 2A (PP2A) that allosterically facilitates assembly and activation of PP2A holoenzyme complex consisting PPP2R1A, PPP2R5E (B56ε, regulatory), and PPP2CA subunits. iHAP1 induces dephosphorylation of MYBL2 transcription factor on Ser241, causing irreversible cell cycle arrest of leukemia and other cancer cells in prometaphase. iHAP1 exhibits significant antitumor activity and lack of toxicity in T-ALL xenograft mice models. Normal CD34+ HSPCs are appears to be resistant to iHAP1. iHAP1 does not inhibit dopamine receptor D2.

基本信息

经验(实验)分子式	C₂₀H₁₄ClNO₂S
分子量	367.85
MDL编号	MFCD01245092

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable