KY-05009

产品名称：

1228280-29-2
KY-05009
5-(4-Methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide
5-[(4-Methylbenzoyl)amino]-2-(phenylamino)-4-thiazolecarboxamide

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.
KY-05009 is also known as (5-(4-methylbenzamido)-2-(phenylamino) thiazole-4-carboxamide). It prevents the proliferation induced by interleukin-6 and promotes cell death by blocking Wnt signaling in multiple myeloma (MM) cells. KY-05009 is a novel aminothiazole, which possesses anti-cancer activity in human colorectal cancer cells. KY-05009 prevents migration and invasion stimulated by TGF-β1 (transforming growth factor beta 1).

基本信息

经验(实验)分子式	C₁₈H₁₆N₄O₂S
分子量	352.41
PubChem化学物质编号	329825926
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	light yellow to dark yellow
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃
SMILES string	NC(C1=C(NC(C2=CC=C(C)C=C2)=O)SC(NC3=CC=CC=C3)=N1)=O
InChI	1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24)
InChI key	WCEDGRTWDSHZHF-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable