L-655,708

产品名称：

130477-52-0
L-655,708
L-655708
Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate

产品介绍：

产品说明

应用

L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.

包装

5, 25 mg in glass bottle

生化/生理作用

L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.
Novel ligand selective for the benzodiazepine site of GABA_A receptors which contain the α₅ subunit.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₁₈H₁₉N₃O₄
分子量	341.36
MDL编号	MFCD02684528
PubChem化学物质编号	24278527
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
溶解性	DMSO: ≥6.0 mg/mL (Warmed) H₂O: insoluble
创始人	Merck & Co., Inc., Kenilworth, NJ, U.S.
SMILES string	CCOC(=O)c1ncn2-c3ccc(OC)cc3C(=O)N4CCCC4c12
InChI	1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1
InChI key	YKYOQIXTECBVBB-AWEZNQCLSA-N
Gene Information	human ... GABRA5(2558)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)