LHVS

产品名称：

170111-28-1
LHVS
Mu-Leu-HphVSPh
Morpholinurea-leucine-homophenylalanine-vinylsulfone-phenyl
(S)-(E)-3-(4-Morpholine-carbonylleucyl)amino-5-phenyl-1-phenylsulfonyl-1-pentene
Mu-Leu-Hph-VSPh

产品介绍：

产品说明

生化/生理作用

LHVS is an irreversible, potent and selective cathepsin S inhibitor (CatS Ki = 5.9 nM; CatO2/L/B Ki = 0.23/0.72/39 μM, Cruzain Ki = 0.22 μM) that targets CatS active site thiol for covalent modification via its vinyl sulfone moiety. LHVS is a useful tool for studyting CatS-mediated responses in cultures (typical dosing ranges: 25 nM to 10μM) and in animals in vivo, including CatS-induced itch in mice (30 mg/kg sc.), morphine-induced antinociceptive tolerance in rats (50 nmol/rat itrathetically) and mechanical hyperalgesia in nerve-injured rats (3-30 mg/kg sc.).

基本信息

经验(实验)分子式	C₂₈H₃₇N₃O₅S
分子量	527.68
MDL编号	MFCD32201152

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(N[C@@H](CC(C)C)C(N[C@H](/C=C/S(=O)(C1=CC=CC=C1)=O)CCC2=CC=CC=C2)=O)N3CCOCC3

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable