Mps1-IN-3

产品名称：

Mps1-IN-3
1-(4-(6-(2-(Isopropylsulfonyl)phenylamino)-9H-purin-2-ylamino)-3-methoxyphenyl)piperidin-4-ol

产品介绍：

产品说明

一般描述

Monopolar spindle 1 (Mps1) protein contains a TPR (tetratricopeptide repeat) motif at its N-terminal and a C-terminal kinase domain.

应用

Mps1-IN-3 has been used in 2D-proliferation and 3D-organotypic culture outgrowth assays.

包装

5, 25 mg in glass bottle

生化/生理作用

Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1, also known as TTK), a Dual-specificity kinase required for spindle pole body duplication and spindle checkpoint function. Mps1-IN-3 inhibited Mps1 kinase activity with an IC₅₀ value of 50 nM inhibited the proliferation of U251 glioblastoma cells as determined by cell counting with an IC₅₀ value of approximately 5 μM, and sensitized glioblastoma cells to vincristine in orthotopic mouse models.
Mps1 mediates phosphorylation of kinetochore scaffold 1.

基本信息

经验(实验)分子式	C₂₆H₃₁N₇O₄S
分子量	537.63
PubChem化学物质编号	329825614
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	light yellow to dark yellow
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃
SMILES string	OC1CCN(C2=CC=C(NC3=NC(NC=N4)=C4C(NC5=C(S(=O)(C(C)C)=O)C=CC=C5)=N3)C(OC)=C2)CC1
InChI	1S/C26H31N7O4S/c1-16(2)38(35,36)22-7-5-4-6-20(22)29-25-23-24(28-15-27-23)31-26(32-25)30-19-9-8-17(14-21(19)37-3)33-12-10-18(34)11-13-33/h4-9,14-16,18,34H,10-13H2,1-3H3,(H3,27,28,29,30,31,32)
InChI key	OFRMASLPWOMYHN-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable