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MRS 1754 hydrate

品牌
Sigma-Aldrich
货号
M6316
规格纯度
≥98% (HPLC), solid
参考价格
3218.16 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
MRS 1754 hydrate
8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
产品介绍:

产品说明

应用

MRS 1754 hydrate has been used as an adenosine receptor A2B (RA2B) antagonist:

  • to study its effects on endothelial nitric oxide synthase (eNOS) phosphorylation induced by short-term acetate stimulation in human umbilical vein endothelial cells (HUVECs)
  • blastema formation in zebrafish
  • to serve as a positive control in the anti-sickling assay and to study the role of RA2B in the same

包装

5, 25 mg in glass bottle

生化/生理作用

MRS 1754 hydrate is a p-cyanoanilide xanthine derivative. It might act as a potential anti-asthmatic drug.
MRS 1754 hydrate is a potent A2B adenosine receptor antagonist.

特点和优势

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律信息

Manufactured and sold under license from Adenosine Therapeutics LLC.

基本信息

经验(实验)分子式C26H26N6O4 · xH2O
分子量486.52 (anhydrous basis)
MDL编号MFCD11046004
PubChem化学物质编号24278793
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
颜色 off-white
溶解性DMSO: soluble >10 mg/mL
储存温度room temp
SMILES stringO.CCCN1C(=O)N(CCC)c2[nH]c(nc2C1=O)-c3ccc(OCC(=O)Nc4ccc(cc4)C#N)cc3
InChI1S/C26H26N6O4.H2O/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19;/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30);1H2
InChI keyZACJDWOPQROWIK-UHFFFAOYSA-N
Gene Informationhuman ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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