MS436

产品名称：

1395084-25-9
MS436
MS 436
MS-436
(E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide

产品介绍：

产品说明

生化/生理作用

MS436 is a diazobenzene-based potent BRD4 inhibitor with selective affinity toward the first bromodomain (BrD) of BRD4 (BRD4 BrD1 Ki <85 nM vs. BRD4 BrD2 Ki = 340 nM; IC50 = 460 nM/BRD4 BrD1 vs. 1.29 μM/BRD4 BrD2, 4.95 μM/CBP BrD, 20.29 μM/PCAF BrD). MS436 is a useful tool for probing BRD4-dependent cellular functions, including NF-κB-mediated proinflammatory response in RAW264.7 murine macrophages (IC50 in μM = 4.9/3.8 against LPS-induced IL-6/NO production), human and murine embryonic stem cell (ESC) pluripotency maintenance (10 μM), telomere elongation in mTERT/mTR-overexpressing murine fibroblasts (5 μM), and bioenergetic deficiency caused by mitochondrial complex I (CI)-mutation in human cybrid cells (0.9 μM).

基本信息

经验(实验)分子式	C₁₈H₁₇N₅O₃S
分子量	383.42
MDL编号	MFCD27992062

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	faint brown to dark red
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=S(C(C=C1)=CC=C1/N=N/C2=C(N)C=C(O)C(C)=C2)(NC3=NC=CC=C3)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable