产品说明
应用
N,N-Dimethylsphingosine has been used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) for psychosine quantification in fibroblasts from twitcher (TWI) and wild type mice. It has also been used as an inhibitor of sphingosine kinase (SphK) to investigate the role of SphK in enhancing lipopolysaccharide (LPS)-mediated chemokine expression.
包装
5, 25 mg in glass bottle
生化/生理作用
N,N-Dimethylsphingosine (DMS) is an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines. N,N-Dimethylsphingosine is a potent inhbitor of sphingosine kinase. DMS levels are elevated in the spinal cord, and contributes to allodynia, in a transected-nerve model of neuropathic pain.
特点和优势
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基本信息
| 经验(实验)分子式 | C20H41NO2 |
| 分子量 | 327.55 |
| MDL编号 | MFCD02259309 |
| PubChem化学物质编号 | 329825316 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | film |
| 颜色 | colorless |
| 储存温度 | −20℃ |
| SMILES string | OC[C@@](N(C)C)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC |
| InChI | 1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1 |
| InChI key | YRXOQXUDKDCXME-YIVRLKKSSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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