产品说明
生化/生理作用
NSC15520 is an inhibitor of the N-terminal protein interaction domain of Replication Protein A (RPA), the major single-stranded DNA binding protein in eukaryotes, which is required for DNA replication, DNA repair, DNA recombination, and DNA damage response signaling. It has been shown to block the association of RPA to p53 and RAD9. In pluripotent stem cells, NSC 15520 increased targeted nucleotide substitutions in CRISPER reactions using Cas9n and Cpf1. It has been used along with a group of other small molecules to achieve a 2.8 to 7.2-fold increase in precision gene editing with Cas9.
基本信息
| 经验(实验)分子式 | C24H34O6 |
| 分子量 | 418.52 |
| MDL编号 | MFCD00057343 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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