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P5091

品牌
Sigma-Aldrich
CAS
882257-11-6
货号
SML0770
规格纯度
≥98% (HPLC)
参考价格
1682.59 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
882257-11-6
P5091
1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]-ethanone; 1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone
产品介绍:

产品说明

应用

P5091 has been used:

  • as a ubiquitin specific peptidase 47 (USP47) inhibitor in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cellular viability of MCF-10A cells
  • as a USP7 inhibitor to study the regulatory role for USP7 on inflammasome activation
  • as USP7 inhibitor in drug susceptibility assays to study its effect on bone marrow−resident tumor cells (BMRTCs)/ circulating tumor cells (CTCs)

包装

5, 25 mg in glass bottle

生化/生理作用

P5091 plays an important role in ovarian cancer, as it can prevent the growth of cells and can promote necrosis and apoptosis.
P5091 is a cell permeable, potent and specific inhibitor of deubiquitylating enzyme USP7 (Ubiquitin-Specific Protease-7) that induces HDM2 polyubiquitylation and accelerates degradation of HDM2. P5091 induces apoptosis in MM cells resistant to conventional and bortezomib therapies. P5091 inhibits tumor growth and prolongs survival in animal models of cancer.

基本信息

经验(实验)分子式C12H7Cl2NO3S2
分子量348.22
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色light yellow to dark yellow
溶解性DMSO: 10 mg/mL, clear
储存温度2-8℃

安全信息

象形图GHS06
警示用语:Danger
危险声明H301 - H413
预防措施声明P273 - P301 + P310 + P330
危险分类Acute Tox. 3 Oral - Aquatic Chronic 4
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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