P5091

产品名称：

882257-11-6
P5091
1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]-ethanone; 1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone

产品介绍：

产品说明

应用

P5091 has been used:

as a ubiquitin specific peptidase 47 (USP47) inhibitor in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cellular viability of MCF-10A cells
as a USP7 inhibitor to study the regulatory role for USP7 on inflammasome activation
as USP7 inhibitor in drug susceptibility assays to study its effect on bone marrow−resident tumor cells (BMRTCs)/ circulating tumor cells (CTCs)

包装

5, 25 mg in glass bottle

生化/生理作用

P5091 plays an important role in ovarian cancer, as it can prevent the growth of cells and can promote necrosis and apoptosis.
P5091 is a cell permeable, potent and specific inhibitor of deubiquitylating enzyme USP7 (Ubiquitin-Specific Protease-7) that induces HDM2 polyubiquitylation and accelerates degradation of HDM2. P5091 induces apoptosis in MM cells resistant to conventional and bortezomib therapies. P5091 inhibits tumor growth and prolongs survival in animal models of cancer.

基本信息

经验(实验)分子式	C₁₂H₇Cl₂NO₃S₂
分子量	348.22
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	light yellow to dark yellow
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H413
预防措施声明	P273 - P301 + P310 + P330
危险分类	Acute Tox. 3 Oral - Aquatic Chronic 4
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable