产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.
特点和优势
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
基本信息
| 经验(实验)分子式 | C17H16FN3 · HCl |
| 分子量 | 317.79 |
| MDL编号 | MFCD11112196 |
| PubChem化学物质编号 | 329824019 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to tan |
| 溶解性 | DMSO: ≥20 mg/mL |
| 创始人 | Roche |
| 储存温度 | 2-8℃ |
| SMILES string | Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23 |
| InChI | 1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H |
| InChI key | MKJPYBJBPRFMHL-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H301 - H315 - H319 - H335 |
| 预防措施声明 | P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
