Ru2(μ-N)(NH3)8Cl2]Cl3

产品名称：

27056-01-5
Ru265
Ru2(μ-N)(NH3)8Cl2]Cl3
trans,trans-Octaamminedichloro-μ-nitridodi-Ruthenium(3+) trichloride, Nitride, ruthenium complex

产品介绍：

产品说明

生化/生理作用

Ru265 is a non-cytotoxic, aqueous soluble nitrido-bridged dinuclear Ru(IV) complex that acts as a selective mitochondrial calcium uniporter (MCU) inhibitor via a manner distinct from the oxo-bridged Ru360. Ru265 selectively reduces 100 μM histamine-induced mitochondrial [Ca²⁺] (mCa²⁺), but not cytosolic [Ca²⁺] (cCa²⁺) transient (50 ?M; HeLa) by blocking MCU-mediated mCa²⁺ uptake at a >10-fold greater potency as Ru360 (IC50 ~2.6 nM vs. 30 nM; HEK293T) without effecting mCa²⁺ efflux or membrane potential (ΔΨm). Ru265 (50 μM) protects neonatal rat ventricular myocytes from hypoxia/reoxygenation injury by preventing mPTP opening and mCa²⁺ overload.

基本信息

经验(实验)分子式	Cl₅H₂₄N₉Ru₂
分子量	529.66

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	powder
颜色	white to dark beige
溶解性	H₂O: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	Cl[Ru](N)(N)(N)(N)n[Ru](N)(N)(N)(N)Cl

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable