产品说明
应用
SYUIQ-5 may be used in autophagy and DNA damage-inducing cell signaling studies.
包装
5, 25 mg in glass bottle
生化/生理作用
SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent.
基本信息
| 经验(实验)分子式 | C20H22N4 |
| 分子量 | 318.42 |
| MDL编号 | MFCD17215940 |
| PubChem化学物质编号 | 329824555 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | yellow |
| 溶解性 | DMSO: ≥20 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | CN(C)CCCNc1c2ccccc2nc3c4ccccc4[nH]c13 |
| InChI | 1S/C20H22N4/c1-24(2)13-7-12-21-18-14-8-3-5-10-16(14)22-19-15-9-4-6-11-17(15)23-20(18)19/h3-6,8-11,23H,7,12-13H2,1-2H3,(H,21,22) |
| InChI key | CTDCVGDSVHUYMA-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H400 |
| 预防措施声明 | P273 |
| 危险分类 | Aquatic Acute 1 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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