Tasisulam

产品名称：

519055-62-0
Tasisulam
LY 573636
LY-573636
N-[(5-Bromo-2-thienyl)sulfonyl]-2,4-dichlorobenzamide
N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide
LY573636
N-(5-Bromothiophen-2-ylsulfonyl)-2,4-dichlorobenzamide

产品介绍：

产品说明

生化/生理作用

Tasisulam (LY573636) is a SPLAM (SPLicing inhibitor sulfonAMide) that bridges RNA binding motif protein 39 (RBM39; CAPERα, HCC1) and DCAF15 for interaction, thereby promoting (CUL4-DDB1-DDA1-DCAF15) E3 ubiquitin ligase complex-mediated RBM39 ubiquitination and subsequent proteasomal degradation. Tasisulam exerts selective toxicity in parental HCT116 cancer cultures (IC₅₀ = 6.5 μM), but not those harboring non-CUL4-DCAF15-associating RBM39 G268V mutant even at a high concentration of 50 μM.

基本信息

经验(实验)分子式	C₁₁H₆BrCl₂NO₃S₂
分子量	415.11
MDL编号	MFCD11973637

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable