UNC3866 trifluoroacetate salt

产品名称：

UNC3866 trifluoroacetate salt
N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-Serine methyl ester trifluoroacetate

产品介绍：

产品说明

生化/生理作用

UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ∼100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression.
Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1

基本信息

经验(实验)分子式	C₄₃H₆₆N₆O₈
分子量	795.02

产品性质

测定	≥98% (HPLC)
形式	lyophilized powder (white)
颜色	white to off-white
运输	wet ice
储存温度	−20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable