VU0238429

产品名称：

1160247-92-6
VU0238429
1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. M5 is thought to regulate cerebral blood flow, and activation of M5 may be therapeutic for Alzheimer′s disease. VU0238429 is the first reported M5-selective small molecule of any kind. It is >30-fold more selective for M5 over M1, M2, M3, and M4.

特点和优势

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₁₇H₁₂F₃NO₄
分子量	351.28
MDL编号	MFCD16618396
PubChem化学物质编号	329829052
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	orange
溶解性	DMSO: ≥20 mg/mL
储存温度	2-8℃
SMILES string	COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1
InChI	1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3
InChI key	CKLGZXFOLMHCMC-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H319 - H400
预防措施声明	P273 - P305 + P351 + P338
危险分类	Aquatic Acute 1 - Eye Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable