Z-脯氨酸

产品名称：

88795-32-8
Z-Pro-prolinal
Phenylmethyl (2S)-2-[(2S)-2-formylpyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
ZPP
Cbz-Pro-Prolinal
Z-pro-pro-CHO
Z-prolyl-prolinal
Z-Pro-Pro-CHO, Z-PP-CHO
N-Benzyloxycarbonyl-L-prolyl-L-prolinal
Z-脯氨酸

产品介绍：

产品说明

应用

Z-Pro-prolinal was used to inhibit activation of rekallikrein in Prolylcarboxypeptidase assay in HUVECs. ZPP was also used in assays to identify enzymes important in the processing of angiotensin peptides in human glomerular endothelial cells.

包装

5, 25 mg in glass bottle

生化/生理作用

Z-Pro-prolinal is a potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = 1 nM.

POP has been connected to memory and mood through regulation of the brain levels of its peptide substrates, which include AVP, substance P, neurotensin and TRH and is a potential target in cognitive function, memory, and neurodegenerative disorders such as amnesia, Alzheimer′s disease, and depression. POP has recently been reported to be involved in the release of the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (Ac-SDKP) from its precursor, 43-mer thymosin β4 (Tβ4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.

基本信息

经验(实验)分子式	C₁₈H₂₂N₂O₄
分子量	330.38
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to tan
溶解性	DMSO: ≥10 mg/mL
储存温度	−20℃
InChI	1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1
InChI key	ORZXYSPOAVJYRU-HOTGVXAUSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H319
预防措施声明	P301 + P312 + P330 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable