(R,S)-AM1241

产品名称：

444912-48-5
(R,S)-AM1241
(R,S)-3-(2-Iodo-5-nitrobenzoyl)-1-(1-methyl-2-piperidinylmethyl)-1H-indole

产品介绍：

产品说明

应用

(R,S)-AM1241 has been used as a cannabinoid CB2 agonist:

to study its inhibitory effect on bone cancer-induced pain and bone loss
to study the effect of its interaction with 17βestradiol on proliferation activity in primary human osteoblasts
to evaluate the sites of CB2 mediated antinociception in vivo.

包装

5, 25 mg in glass bottle

生化/生理作用

AM1241 acts as an antinociceptive agent in several animal pain models. It has a potential to delay disease progression in amyotrophic lateral sclerosis (ALS) mouse model. Intrathecal, intravenous or intraperitoneal administration of AM1241 reduces hyperalgesia and allodynia in neuropathic rats.
Selective CB₂ cannabinoid receptor agonist

基本信息

经验(实验)分子式	C₂₂H₂₂IN₃O₃
分子量	503.33
MDL编号	MFCD11045986
PubChem化学物质编号	24891092
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
drug control	regulated under CDSA - not available from sigma-aldrich Canada
颜色	yellow
溶解性	DMSO: ~18 mg/mL at 60 ℃
SMILES string	CN1CCCCC1Cn2cc(C(=O)c3cc(ccc3I)[N+]([O-])=O)c4ccccc24
InChI	1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3
InChI key	ZUHIXXCLLBMBDW-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H315 - H319 - H334 - H335
预防措施声明	P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves