Amyloid-β Forty-Two Inducer 4

产品名称：

866893-90-5
Aftin-4
Amyloid-β Forty-Two Inducer 4
(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
N6-Methyl-(R)-roscovitine

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.

基本信息

经验(实验)分子式	C₂₀H₂₈N₆O
分子量	368.48

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	protect from light
颜色	white to beige
溶解性	DMSO: 25 mg/mL, clear
储存温度	−20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3