Atopaxar hydrobromide

产品名称：

751475-53-3
Atopaxar hydrobromide
E-5555
ER 172594-06
ER-172594-00 hydrobromide
2-(5,6-Diethoxy-7-fluoro-1,3-dihydro-1-imino-2H-isoindol-2-yl)-1-[3-(1,1-dimethylethyl)-4-methoxy-5-(4-morpholinyl)phenyl]ethanone, monohydrobromide
E 5555
1-(3-tert-Butyl-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-2H-isoindol-2-yl)ethanone hydrobromide
E5555

产品介绍：

产品说明

生化/生理作用

Atopaxar (E5555) is an orally active, potent and selective thrombin receptor (protease-activated receptor; PAR1) antagonist (IC50 = 19 nM/E5555 vs. 490 nM/TRAP against 10 nM haTRAP for PAR-1 binding on human platelet membranes) that inhibits platelet aggregation induced by thrombin or TRAP T (human platelet IC50 = 64/31 nM against 1 u/mL Thrombin/5 μM TRAP; guinea pig IC50 = 13/97 nM against 2 u/mL Thrombin/20 μM TRAP), but not ADP, U46619, collagen, PAR-4ap or PAF. Atopaxar exhibits antithrombotic efficacy in guinea pigs and rats in vivo (10, 30, 100 mg/kg p.o.).

基本信息

经验(实验)分子式	C₂₉H₃₈FN₃O₅ · xHBr
分子量	527.63 (free base basis)

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(CN1C(C2=C(C(OCC)=C(C=C2C1)OCC)F)=N)C(C=C3N4CCOCC4)=CC(C(C)(C)C)=C3OC.[xHBr]

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable