C-178

产品名称：

329198-87-0
C-178
C 178
C178
N-(Dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide
N-Dibenzofuran-3-yl-5-nitrofuran-2-carboxamide
N-3-Dibenzofuranyl-5-nitro-2-furancarboxamide

产品介绍：

产品说明

生化/生理作用

C-178 is a potent and selective inhibitor against murine, but not human, stimulator of interferon genes (STING) via covalent modifiation of mSTING Cys91. C-178 inhibits mSTING-mediated IFNβ reporter activity (IC50 <500 nM) without affecting RIG-I, and blocks (0.5 μM) downstream TBK1 phosphorylation induction by STING agonist CMA (1.4 h) in mSTING-expressing HEK293T cells.

基本信息

经验(实验)分子式	C₁₇H₁₀N₂O₅
分子量	322.27
MDL编号	MFCD01146392

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	faint yellow to dark brown
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC(OC3=C4C=CC=C3)=C4C=C2

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable