Cortexolone 17α-propionate

产品名称：

19608-29-8
Clascoterone
21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione
CB-03-01
Cortexolone 17α-propionate
C17P

产品介绍：

产品说明

生化/生理作用

Clascoterone is a high-affinity androgen receptor (AR) antagonist (antiandrogen) that antagonizes testosterone-stimulated transcription activity (in reporter cells) as well as DHT-induced production of lipids and inflammatory cytokines (in human sebocytes) in cultures. When applied topically, clascoterone is as active as cyproterone acetate, and 2-, 3-, and 4-times, respectively, more active than finasteride, flutamide, and progesterone in vivo (local antiandrogenic activity in hamster′s flank organ; 100-400 μg/50 μL acetone/animal).

基本信息

经验(实验)分子式	C₂₄H₃₄O₅
分子量	402.52
MDL编号	MFCD18384978

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	CCC(O[C@]1(C(CO)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O