CU-CPT9a

产品名称：

2165340-32-7
CU-CPT9a
2-Methyl-4-(7-methoxyl-4-quinolinyl)-phenol
Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl

产品介绍：

产品说明

生化/生理作用

CU-CPT9a is a potent and selective inhibitor of Toll-like receptor 8 (TLR8). It binds to TLR8 at a site different from current small-molecule TLR7/8 agonists, stabilizing the TLR8 dimer in its resting state, thus preventing TLR8 activation It exhibited an IC50 value of 0.5 nM and blocked TLR8 activation induced by either resiquimod (R848) or ssRNA without affecting the closely related TLR7 or cells expressing other TLRs. CU-CPT9a also suppressed TNF-α levels in a dose-dependent manner in cells from patients with rheumatoid arthritis.

基本信息

经验(实验)分子式	C₁₇H₁₅NO₂
分子量	265.31
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	CC1=CC(C2=CC=NC3=CC(OC)=CC=C23)=CC=C1O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable