ETP-47799

产品名称：

923596-52-5
ETP-47799
ETP 47799
CDK8/19i-CNIO-47799
CDK8/19i-47799
N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine
Lck-IN-1
ETP47799

产品介绍：

产品说明

生化/生理作用

ETP-47799 is a potent and CDK8-/CDK19-selective cyclin-dependent kinase inhibtor (CDK8/19 IC50 = 2.9/14.1 nM; CDK1/5/9 IC50 = 275/239/124 nM; CDK2/4/6/7 IC50 >1 μM; GSK3β IC50 = 3.14 μM) with additional potency against PDGFRα (IC50 = 3.5 nM). ETP-47799 ( 0.4 μM or 1.1 μM) induces and stabilizes the naive state of murine and human pluripotent stem cells (PSCs) with better efficiency than the commonly used MEK/GSK3 inhibitor cocktail (1μM PD0325901, 1.5μM CHIR 99021).

基本信息

经验(实验)分子式	C₁₄H₁₅N₅
分子量	253.30

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	CCCNC1=NN2C(C=C1)=NC=C2C3=CC=NC=C3

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable