GSK046

产品名称：

2474876-09-8
GSK046
4-acetamido-3-fluoro-N-(trans-4-hydroxycyclohexyl)-5-[(1S)-1-phenylethoxy]benzamide; 4-Acetamido-3-fluoro-N-((1R,4S)-4-hydroxycyclohexyl)-5-((S)-1-phenylethoxy)benzamide

产品介绍：

产品说明

生化/生理作用

GSK046 (iBET-BD2) is a potent and highly selective inhibitor of bromodomain BD2 of BRD2, BDR3, BRD4, BRDT. GSK046 inhibits the production of effector cytokines, including IFN-g, interleukin- 17A (IL-17A), and IL-22 in primary CD4+ T cell cultures without effecting proliferation. It appears that BD2-selective inhibition by GSK046 specifically affects the induction of gene expression while leaving the maintenance of established transcription programs largely unaltered.

基本信息

经验(实验)分子式	C₂₃H₂₇FN₂O₄
分子量	414.47

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable