GSK983

产品名称：

827591-02-6
GSK983
N-[(1R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-2-pyridinecarboxamide
GSK260983

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

GSK983 is a tetrahydrocarbazole or a broad spectrum antiviral lead compound. GSK983 acts by stimulating a subset of interferon-stimulated genes.
GSK983 blocks RNA virus replication with EC₅₀ values of 10–40 nM, and also blocks cell proliferation. GSK983 acts by inhibition of dihydroorotate dehydrogenase (DHODH), necesssary for pyrimidine biosynthesis. Exogenous deoxycytidine was able to reduce GSK983 cytotoxicity, allowing cells to synthesize DNA, but still preventing RNA virus replication. GSK983 was active against dengue fever and Venezuelan equine encephalitis viruses.

基本信息

经验(实验)分子式	C₁₈H₁₆ClN₃O
分子量	325.79
MDL编号	MFCD28978021
PubChem化学物质编号	329826082
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D +175 to +195°, c = 1 in methylene chloride
储存条件	protect from light
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃
SMILES string	ClC1=CC=C(NC2=C3CCC[C@H]2NC(C4=NC=CC=C4)=O)C3=C1

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319
预防措施声明	P301 + P312 + P330 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable