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GW9508

品牌
Sigma-Aldrich
CAS
885101-89-3
货号
G9797
规格纯度
≥98% (HPLC)
参考价格
1572.9 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
885101-89-3
GW9508
4-(3-Phenoxybenzylamino)phenylpropionic acid
产品介绍:

产品说明

应用

GW9508, a selective FFA1/GPR40 agonist, may be used to differentiate and characterize the free fatty acid receptor FFA1/GPR40. GW9508 is used to study the role of FFA1/GPR40 receptors in processes such as the free fatty acid enhancement of glucose-stimulated insulin release and type 2 diabetes. GW9508 is used to study the process by which FFA1/GPR40 receptors protect from ovariectomy-induced bone loss in vivo though inhibition of osteoclast differentiation and suppress complete Freund′s adjuvant (CFA)-Induced inflammatory chronic pain.
GW9508 has been used in:

  • cell proliferation assay in pancreatic cancer cells
  • in motility assay in melanoma cells
  • cell invasion assay in colon cancer cells

包装

5, 25 mg in glass bottle

生化/生理作用

GW9508 is a selective FFA1/GPR40 agonist. GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have now been identified as free fatty acids (FFAs). The receptor, named FFA receptor 1, has been implicated in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release. GW9508 showed greater than 500-fold selectivity for GPR40 over GPR41 and GPR43 and possessed a good in vitro and in vivo profile with excellent bioavailability. GW9508 stimulated intracellular Ca2+ mobilization in human embryonic kidney HEK-293 cells expressing GPR40 or GPR120, but not in the parent HEK-293 cell line. GW9508 dose dependently potentiated glucose-stimulated insulin secretion in MIN6 cells, but not in primary rat or mouse islets. GW9508 potentiates the KCl-mediated increase in insulin secretion in MIN6 cells.

基本信息

经验(实验)分子式C22H21NO3
分子量347.41
MDL编号MFCD09753282
PubChem化学物质编号329799992
NACRESNA.25

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white
溶解性DMSO: >20 mg/mL
储存温度2-8℃
SMILES stringOC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1
InChI1S/C22H21NO3/c24-22(25)14-11-17-9-12-19(13-10-17)23-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15,23H,11,14,16H2,(H,24,25)
InChI keyDGENZVKCTGIDRZ-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Sigma-Aldrich

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