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Kurarinone

品牌
Sigma-Aldrich
CAS
34981-26-5
货号
SML1843
规格纯度
≥98% (HPLC)
参考价格
2353.43 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
34981-26-5
Kurarinone
(2S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-5-methoxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-4H-1-benzopyran-4-one
Marini
(-)-Kurarinone
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Kurarinone, a flavanone from Sophora flavescens roots, is a potent activator of the large-conductance calcium-activated potassium channel (BKCa channel). Kurarinone exhibits strong preference to potentiate the homomeric BKCa channel composed only of the α subunits. Kurarinone reduces acetylcholine induced contraction of rat urinary bladder strips and decreased the voiding frequency in a rat OAB model. Kurarinone exhibits cytotoxic and antiinflamatory activity. Kurarinone sensitizes TRAIL-induced tumor cell apoptosis via suppression of NF-KB-dependent cFLIP expression.

基本信息

经验(实验)分子式C26H30O6
分子量438.51

产品性质

质量水平100
生物来源 (isolated from Caragana sinica)
测定≥98% (HPLC)
形式powder
储存条件protect from light
颜色 white to beige
溶解性DMSO: 20 mg/mL, clear
储存温度−20℃
SMILES stringCC([C@H](CC=C(C)C)CC1=C2C(C(C[C@@H](C3=CC=C(O)C=C3O)O2)=O)=C(OC)C=C1O)=C
InChI1S/C25H28O6/c1-13(2)5-6-15(14(3)4)9-18-20(28)11-21(29)24-22(30)12-23(31-25(18)24)17-8-7-16(26)10-19(17)27/h5,7-8,10-11,15,23,26-29H,3,6,9,12H2,1-2,4H3
InChI keyXRYVAQQLDYTHCL-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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