Loreclezole

产品名称：

117857-45-1
Loreclezole
R-72063
1-[(Z)-2-Chloro-2-(2,4-dichlorophenyl)vinyl]-1,2,4-triazole
1-[(1Z)-2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole
R72063
R 72063

产品介绍：

产品说明

生化/生理作用

Loreclezole (R72063) is a sedative and anticonvulsant that exerts subtype-selective positive allosteric modulator (PAM) potency toward beta2 (β₂)- or β₃-containing GABA_A gamma-aminobutyric acid (GABA) receptors (% potentiation by 1 μM Loreclezole of GABA EC20-stimulated current/human α₁βγ₂ = 100/α₁β₂γ₂, 120/α₁β₃γ₂, 13/α₁β₁γ₂; α₁β₂γ₂ EC50 = 1 μM) with >300-fold lower β₁ affinity, while acting as a negative allosteric modulator (NAM) against the homomeric rho1 (ρ1) GABA_A-rho receptor (rat GABA_C IC50 = 0.5 μM against GABA EC10-induced current).

基本信息

经验(实验)分子式	C₁₀H₆Cl₃N₃
分子量	274.53
MDL编号	MFCD00865331

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	room temp
SMILES string	Cl/C(C1=CC=C(Cl)C=C1Cl)=C\N2N=CN=C2
InChI	1S/C10H6Cl3N3/c11-7-1-2-8(9(12)3-7)10(13)4-16-6-14-5-15-16/h1-6H/b10-4-
InChI key	XGLHZTBDUXXHOM-WMZJFQQLSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable