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LY225910

品牌
Sigma-Aldrich
CAS
133040-77-4
货号
L2545
包装型号
规格纯度
≥98% (HPLC)
参考价格
5933.09 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
133040-77-4
LY225910
2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy )phenyl]-4-(3H)-quinazolinone
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Cholecystokinin is expressed in the gastrointestinal tract and the central nervous system. Cholecystokinin receptor type 2 (CCK2) is a GPCR that is highly expressed in brain and spinal cord. CCK2 is implicated in many brain processes, including mood, anxiety, and pain, through its modulation of GABA neurotransmission.

LY225910 is a potent, selective CCK2 antagonist. LY225910 blocks agonism of CCK2 by CCK-8S, the peptide agonist. LY225910 has been measured in multiple systems, including GABA efflux from cortical cultures, depolarization of spinal cord neurons (via potassium conductance), modulation of excitatory postsynaptic potentials (EPSPs) in nucleus accumbens slices, and enhancement of morphine analgesia.

特点和优势

This compound is featured on the Cholecystokinin and Gastrin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式C27H24BrN3O2
分子量502.40
MDL编号MFCD00907856
PubChem化学物质编号329817399
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 off-white
溶解性DMSO: >20 mg/mL
创始人Eli Lilly
储存温度2-8℃
SMILES stringCC(C)Oc1cccc(c1)N2C(CCc3c[nH]c4ccc(Br)cc34)=Nc5ccccc5C2=O
InChI1S/C27H24BrN3O2/c1-17(2)33-21-7-5-6-20(15-21)31-26(30-25-9-4-3-8-22(25)27(31)32)13-10-18-16-29-24-12-11-19(28)14-23(18)24/h3-9,11-12,14-17,29H,10,13H2,1-2H3
InChI keyKUECXUACQOYKNB-UHFFFAOYSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H301 - H413
预防措施声明P273 - P301 + P310 + P330
危险分类Acute Tox. 3 Oral - Aquatic Chronic 4
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)638.6 - 762.1 °F
闪点(C)337 - 405.6 ℃

Sigma-Aldrich

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