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MGR1

品牌
Sigma-Aldrich
CAS
2361529-46-4
货号
SML2953
规格纯度
≥98% (HPLC)
参考价格
1376.29 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
2361529-46-4
MGR1
2,2-Dimethylpropanoic acid [(1,4,4a,9,9a,10-hexahydro-9,10-dioxo-1,4-ethanoanthracen-5-yl)oxy]methyl ester
JCHD precursor
产品介绍:

产品说明

生化/生理作用

MGR1 is an effective reactive oxygen species (ROS) generator in live cells (dosing range 2-100 μM). MGR1 is activated by intracellular esterases to form JCHD (5-hydroxy-1,4,4a,9a-tetrahydro-1,4-ethanoanthracene-9,10-dione), which in turn, facilitated by a proximal H-bonding hydroxyl group, undergoes keto-enol tautomerism for enhanced superoxide (O2•-) generation upon reacting with molecular oxygen (O2). MGR1, but not its inactive analog MGR2, upregulates cellular ROS, resulting in cell death when used at high concentrations (>5 μM; RAW264.7, THP1, HeLa, MCF7, A549).

基本信息

经验(实验)分子式C22H24O5
分子量368.42

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringO=C1C2C(C(C3=C1C=CC=C3OCOC(C(C)(C)C)=O)=O)C4C=CC2CC4

Sigma-Aldrich

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