N-Desethyl sunitinib hydrochloride

产品名称：

356068-97-8
N-Desethyl sunitinib hydrochloride
5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-ethylaminoethyl)amide hydrochloride
SU 12662 hydrochloride
SU12662 hydrochloride
N-Desethylsunitinib hydrochloride
N-[2-(Ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide hydrochloride

产品介绍：

产品说明

生化/生理作用

N-Desethyl sunitinib is a multi-target tyrosine kinase inhibitor that is a major active metabolite of an anticancer drug sunitinib. N-Desethyl sunitinib has a similar kinase inhibitory effect as sunitinib. In patients, plasma sunitinib and N-desethyl sunitinib accounts for 42% and 24%, respectively. Thus N-desethyl sunitinib accounts for one third of the therapeutic effect of oral sunitinib.

基本信息

经验(实验)分子式	C₂₀H₂₃FN₄O₂ · xHCl
分子量	370.42 (free base basis)
MDL编号	MFCD18252482

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear (warmed)
储存温度	2-8℃

安全信息

象形图
警示用语：	Warning
危险声明	H361d - H373 - H410
预防措施声明	P202 - P260 - P273 - P280 - P308 + P313 - P391
危险分类	Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable