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PaPE-1

品牌
Sigma-Aldrich
货号
SML1876
包装型号
规格纯度
≥98% (HPLC)
参考价格
1399.43 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
PaPE-1
(S)-5-(4-Hydroxy-3,5-dimethyl-phenyl)-indan-1-ol
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

PaPE-1 is a "Pathway Preferential Estrogen" that activates the extranuclear signaling pathway without activating the nuclear signaling pathway. PaPE-1 bound 50,000-fold less well to ERα and Erβ estrogen receptors. PaPE-1 activated extranuclear-initiated ER-regulated genes, but showed essentially no activation of nuclear-initiated estrogen receptor (ER) gene targets such as the progesterone receptor. Unlike estradiol (E2), PaPE-1 did not stimulate proliferation of MCF-7 breast cancer cells. Like estradiol, PaPE-1 strongly activated MAPK and mTOR pathway. Instead, it showed preferential estrogen-like activity in non-reproductive (metabolic and vascular) tissues, reducing body weight gain and fat accumulation in ovariectomized mice and accelerating repair of endothelial damage in the vascualture.

基本信息

经验(实验)分子式C17H18O2
分子量254.32
MDL编号MFCD30723184

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 25 mg/mL, clear
储存温度2-8℃
SMILES stringO[C@H]1CCC2=C1C=CC(C3=CC(C)=C(O)C(C)=C3)=C2

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319
预防措施声明P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3

Sigma-Aldrich

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