S1QEL1.1

产品名称：

897613-29-5
S1QEL1.1
N1-(3-acetamidophenyl)-N2-(2-(4-methyl-2-(p-tolyl)thiazol-5-yl)ethyl)oxalamide
S1QEL

产品介绍：

产品说明

应用

S1QEL1.1 has been used as a reverse electron transport (RET)-induced mitochondrial (mito) reactive oxygen species (ROS) suppressor:

to investigate the role of mitochondrial-derived superoxide in triggering ferroptosis
to study the mechanism involved in the regulation of anti-fungal responses of macrophages against Aspergillus infection
in combination with mito-antioxidant to study their influence on mitochondria-derived H₂O₂ in cancer cells
to determine the effect of oxidative stress depletion on myoblast differentiation

生化/生理作用

S1QEL1.1 is a suppressor of mitochondrial respiratory complex I site IQ electron leak, suppressing superoxide and/or H₂O₂ production without altering oxidative phosphorylation. S1QEL1.1 had an IC50 values of 70 nM against superoxide-H₂O₂ production from site IQ. It decreased caspase activation in a in a cardiomyocyte cell model of ER stress and decreased ischemia-reperfusion injury in the Langendorff-perfused mouse heart model.
Suppressors of the site IQ electron leak (S1QEL)1.1 reduces cytokine secretion and fungicidal activity of macrophages infected with swollen A. fumigatus conidia by suppressing reverse electron transport (RET)-induced mitochondrial reactive oxygen species (ROS).

基本信息

经验(实验)分子式	C₂₃H₂₄N₄O₃S
分子量	436.53

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
运输	wet ice
储存温度	−20℃
SMILES string	CC1=C(CCNC(C(NC2=CC=CC(NC(C)=O)=C2)=O)=O)SC(C3=CC=C(C)C=C3)=N1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable