Safinamide mesylate salt

产品名称：

202825-46-5
Safinamide mesylate salt
(S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;

产品介绍：

产品说明

应用

Safinamide mesylate salt has been used as a reference drug to study its inhibitory effect on human monoamine oxidases (hMAO-A and hMAO-B).
Safinamide mesylate salt may be used in cell signaling studies.

包装

5, 25 mg in glass bottle

生化/生理作用

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.
Safinamide mesylate prevents dopamine reuptake and is effective in the treatment of epilepsy and Parkinson′s disease.

特点和优势

This compound is featured on the Calcium Channels and Dopamine and Norepinephrine Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₁₇H₁₉FN₂O₂ · xCH₄O₃S
分子量	302.34 (free base basis)
MDL编号	MFCD15145475
PubChem化学物质编号	329825096
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D +9.5 to +14°, c = 1 (95% acetic acid)
颜色	white to tan
溶解性	H₂O: ≥15 mg/mL
储存温度	2-8℃
SMILES string	CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
InChI	1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1
InChI key	YKOCHIUQOBQIAC-YDALLXLXSA-N
Gene Information	human ... MAOB(4129)

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H319 - H361d
预防措施声明	P202 - P264 - P270 - P301 + P312 - P305 + P351 + P338 - P308 + P313
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable