产品说明
应用
Safinamide mesylate salt has been used as a reference drug to study its inhibitory effect on human monoamine oxidases (hMAO-A and hMAO-B).
Safinamide mesylate salt may be used in cell signaling studies.
包装
5, 25 mg in glass bottle
生化/生理作用
Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.
Safinamide mesylate prevents dopamine reuptake and is effective in the treatment of epilepsy and Parkinson′s disease.
特点和优势
This compound is featured on the Calcium Channels and Dopamine and Norepinephrine Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
| 经验(实验)分子式 | C17H19FN2O2 · xCH4O3S |
| 分子量 | 302.34 (free base basis) |
| MDL编号 | MFCD15145475 |
| PubChem化学物质编号 | 329825096 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 旋光性 | [α]/D +9.5 to +14°, c = 1 (95% acetic acid) |
| 颜色 | white to tan |
| 溶解性 | H2O: ≥15 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O |
| InChI | 1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1 |
| InChI key | YKOCHIUQOBQIAC-YDALLXLXSA-N |
| Gene Information | human ... MAOB(4129) |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H302 - H319 - H361d |
| 预防措施声明 | P202 - P264 - P270 - P301 + P312 - P305 + P351 + P338 - P308 + P313 |
| 危险分类 | Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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