产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.
基本信息
| 经验(实验)分子式 | C11H8N2S |
| 分子量 | 200.26 |
| MDL编号 | MFCD00051329 |
| PubChem化学物质编号 | 329824457 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 溶解性 | DMSO: ≥30 mg/mL |
| 储存温度 | −20℃ |
| SMILES string | Nc1nc2c(ccc3ccccc23)s1 |
| InChI | 1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13) |
| InChI key | FECQXVPRUCCUIL-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 - H319 |
| 预防措施声明 | P305 + P351 + P338 |
| 危险分类 | Acute Tox. 4 Oral - Eye Irrit. 2 |
| 储存分类代码 | 11 - Combustible Solids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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