SMBA1

产品名称：

906440-37-7
SMBA1
2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
2-[(2-Nitro-9H-fluoren-9-ylidene)methyl]-phenol

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Small-molecule Bax agonists 1 (SMBA1) is a potent and selective Bax agonist that binds to Bax, induces conformational change which blocks Bax S184 phosphorylation. SMBA1 induces apoptosis in cancer cells and suppresses lung tumor growth in vivo without significant normal tissue toxicity. SMBA1 does not bind to other B-cell lymphoma 2 (Bcl-2) family members.
SMBA1 is an anti-tumor agent. It exhibits anti-proliferative effects against glioblastoma (GBM) cells.

基本信息

经验(实验)分子式	C₂₀H₁₃NO₃
分子量	315.32
PubChem化学物质编号	329825898
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	−20℃
SMILES string	OC(C=CC=C1)=C1/C=C2C(C=CC=C3)=C3C4=C\2C=C([N+]([O-])=O)C=C4
InChI	1S/C20H13NO3/c22-20-8-4-1-5-13(20)11-18-16-7-3-2-6-15(16)17-10-9-14(21(23)24)12-19(17)18/h1-12,22H/b18-11+
InChI key	PEYKRJBXACUOOB-WOJGMQOQSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable