TT-10

产品名称：

2230640-94-3
TT-10
[4-Amino-2-(2-propen-1-ylamino)-5-thiazolyl](5-fluoro-2-thienyl)methanone
N2-Allyl-5-[(5-fluorothiophen-2-yl)carbonyl]thiazole-2,4-diamine
TT 10
TAZ-K
TAZ K

产品介绍：

产品说明

生化/生理作用

TT-10 (TAZ K) is a TAZ (transcriptional coactivator with PDZ-binding motif) activator that promotes cardiomyocytes (CMs) proliferation (fold-increase by 10 μM TT-10 over untreated control = 5.2/rat CMs/40 hrs & 2.6/human iPSC-derived CMs/48 hrs) by activating YAP (YES-associated protein)/TEAD (transcriptional enhancer factor domain) complex-mediated transcription, as well as by exerting antioxidant and antiapoptotic activity. TT-10 ameliorates myocardial infarction-induced cardiac dysfunction in mice in vivo (10 mg/kg i.p.) at least in part via enhancing clonal expansion of existing cardiomyocytes with nuclear YAP expression.

基本信息

经验(实验)分子式	C₁₁H₁₀FN₃OS₂
分子量	283.35

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	NC1=C(C(C2=CC=C(S2)F)=O)SC(NCC=C)=N1

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable