Vosaroxin hydrochloride

产品名称：

175519-16-1
Vosaroxin hydrochloride
1,4-Dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid hydrochloride
Voreloxin hydrochloride
SNS-595 hydrochloride

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Vosaroxin is an anti-cancer quinolone derivative that acts as a DNA intercalator and a topoisomerase II inhibitor, causing p53 independent tumor cell apoptosis. Vosaroxin stabilizes cleavage complexes formed by topoisomerase IIα and IIβ, which results in an accumulation of DNA double-strand breaks. Vosaroxin showed antineoplastic activity in multiple solid tumor and hematologic cancer cell lines and has been in clinical trials for AML.

基本信息

经验(实验)分子式	C₁₈H₁₉N₅O₄S · HCl
分子量	437.90
MDL编号	MFCD13185156

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D +42 to +52°, c = 1 in 0.1 M NaOH
颜色	white to beige
溶解性	H₂O: 1 mg/mL, clear (warmed)
储存温度	−20℃
SMILES string	O=C(C(C(O)=O)=C1)C2=C(N=C(C=C2)N3C[C@@H]([C@H](C3)NC)OC)N1C4=NC=CS4

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable