VU0240551

产品名称：

893990-34-6
VU0240551
VU0240551-2-D4
N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-acetamide
CID 7211972
VU0240551-1
SID 56405457

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

VU0240551 is a potent, selective KCC2 inhibitor. KCC2 is a potassium-chloride exchanger expressed specifically in neurons. KCC2 functions to lower intracellular chloride concentrations below the electrochemical potential of the cells, thereby increasing the hyperexcitability of the neurons. KCC2 activity enhances GABA and other inhibitory neurotransmission and is implicated in pain processing. VU0240551 was discovered in a high-throughput screen, followed by directed medicinal chemistry. VU0240551 is selective for KCC2 over NKCC1. VU0240551 binds competitively to the K+ site and binds noncompetitively to the Cl- site. VU0240551 is the only small molecule with specificity for a KCC family member.

基本信息

经验(实验)分子式	C₁₆H₁₄N₄OS₂
分子量	342.44
MDL编号	MFCD05957363
PubChem化学物质编号	329829046
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
溶解性	DMSO: >20 mg/mL
储存温度	2-8℃
SMILES string	Cc1csc(NC(=O)CSc2ccc(nn2)-c3ccccc3)n1
InChI	1S/C16H14N4OS2/c1-11-9-23-16(17-11)18-14(21)10-22-15-8-7-13(19-20-15)12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H,17,18,21)
InChI key	WJRWSLORVIHRNX-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable