VU0360172 hydrochloride

产品名称：

1309976-62-2
VU0360172 hydrochloride
N-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinamide hydrochloride

产品介绍：

产品说明

生化/生理作用

VU0360172 is a potent (EC50 = 16.6 nM), systemically active positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu5). It is the first orally active mGlu5 PAM to be efficacious in an in vivo preclinical antipsychotic model, producing a dose-dependent reversal of amphetamine-induced hyperlocomotion. It was also found to reduce absence seizures in WAG/Rij rats and to inhibit pain.

基本信息

经验(实验)分子式	C₁₈H₁₅FN₂O · HCl
分子量	330.78
MDL编号	MFCD22683808

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear (warmed)
储存温度	−20℃
SMILES string	FC1=CC=CC(C#CC2=NC=C(C=C2)C(NC3CCC3)=O)=C1.Cl

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable