VX-745

产品名称：

209410-46-8
VX-745
5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα. VX-745 showed 20-fold selectivity for p38α over p38β and a Ki value of 220 nM. VX-745 has been shown to reduce inflammation in an arthritic (AIA) mouse model and to improve performance in aged rats.

其他说明

VX-745 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the VX-745 probe summary on the Chemical Probes Portal website.

基本信息

经验(实验)分子式	C₁₉H₉Cl₂F₂N₃OS
分子量	436.26
MDL编号	MFCD09834070
PubChem化学物质编号	329825979
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	−20℃
SMILES string	FC1=C(SC2=NN(C=N3)C(C=C2)=C(C4=C(Cl)C=CC=C4Cl)C3=O)C=CC(F)=C1
InChI	1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
InChI key	VEPKQEUBKLEPRA-UHFFFAOYSA-N
Gene Information	human ... MAPK14(1432)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3