XAP044

产品名称：

196928-50-4
XAP044
XAP 044
7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

XAP044 is a brain penetrant, potent and selective mGlu7 (metabotropic glutamate receptor subtype 7) antagonist that inhibits lateral amygdala long-term potentiation (LTP) in brain slices from wild type mice. XAP044 binds to a pocket localized in mGlu7′s extracellular Venus flytrap domain (VFTD) close to the binding site of the orthosteric agonist L-glutamate. XAP044 exhibits a wide-spectrum anti-stress, antidepressant- and anxiolytic-like efficacy in rodent behavioral model.

其他说明

Light sensitive. This compound has Iodine and should be kept in the dark.

基本信息

经验(实验)分子式	C₁₅H₉IO₄
分子量	380.13
MDL编号	MFCD00525548
PubChem化学物质编号	329825781

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	protect from light
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3
InChI	1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
InChI key	XXZKJJYWINSUMJ-UHFFFAOYSA-N

安全信息

储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable