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XL413 hydrochloride

品牌
Sigma-Aldrich
CAS
1169562-71-3
货号
SML1401
规格纯度
≥98% (HPLC)
参考价格
1966.13 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
1169562-71-3
XL413 hydrochloride
BMS-863233
(S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
XL-413
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

XL413 is a selective inhibitor of the serine-threonine kinase CDC7 (cell division cycle 7 homolog), a regulator of cell cycle checkpoint control that has been implicated in protecting tumor cells from apoptotic cell death during replication stress. XL413 has an IC50 of 3.4 nM for CDC7, compared to 215 nM, 42 nM and 18 nM for CK2, PIM1 and pMCM2, respectively. XL413 caused significant tumor growth regression in rodent models, causing cell cycle arrest in the late S to G2 phase.

基本信息

经验(实验)分子式C14H12ClN3O2 · xHCl
分子量289.72 (free base basis)
PubChem化学物质编号329825849
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to beige
溶解性H2O: 5 mg/mL, clear
储存温度−20℃
SMILES stringClC1=CC2=C(C=C1)OC3=C2N=C([C@H]4NCCC4)NC3=O.C
InChI1S/C14H12ClN3O2.CH4/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9;/h3-4,6,9,16H,1-2,5H2,(H,17,18,19);1H4/t9-;/m0./s1
InChI keyUYBMDYGAVMHMGF-FVGYRXGTSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P301 + P310 + P330
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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