YM-202074 倍半富马酸盐水合物

产品名称：

299900-84-8
YM-202074 sesquifumarate salt hydrate
YM 202074
YM202074
N-cyclohexyl-6-{[(2-methoxyethyl)(methyl)amino]methyl}-N-methylthiazolo[3,2-a]benzimidazole-2-carboxamide
YM-202074 倍半富马酸盐水合物

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

YM-202074 is a potent and selective allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist. It bound an allosteric site of rat mGluR1 with a Ki value of 4.8 nM. It also inhibited the mGluR1-mediated inositol phosphates production in rat cerebellar granule cells with an IC50 value of 8.6 nM, while showing selectivity over mGluR(2-7).

基本信息

经验(实验)分子式	C₂₂H₃₀N₄O₂S · 1.5C₄H₄O₄ · xH₂O
分子量	588.67 (anhydrous basis)
MDL编号	MFCD16879020
PubChem化学物质编号	329831586
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to off-white
溶解性	DMSO: >20 mg/mL H₂O: >5 mg/mL
储存温度	room temp
SMILES string	O.OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.COCCN(C)Cc1ccc2nc3sc(cn3c2c1)C(=O)N(C)C4CCCCC4.COCCN(C)Cc5ccc6nc7sc(cn7c6c5)C(=O)N(C)C8CCCCC8.COCCN(C)Cc9ccc%10nc%11sc(cn%11c%10c9)C(=O)N(C)C%12CCCCC%12
InChI	1S/3C22H30N4O2S.2C4H4O4.H2O/c31-24(11-12-28-3)14-16-9-10-18-19(13-16)26-15-20(29-22(26)23-18)21(27)25(2)17-7-5-4-6-8-17;25-3(6)1-2-4(7)8;/h39-10,13,15,17H,4-8,11-12,14H2,1-3H3;21-2H,(H,5,6)(H,7,8);1H2/b;;;2*2-1+;
InChI key	MCGFIZFYSARKON-RAMYONIISA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H319
预防措施声明	P301 + P310 + P330 - P305 + P351 + P338
危险分类	Acute Tox. 3 Oral - Eye Irrit. 2
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

YM-202074 sesquifumarate salt hydrate

YM-202074 倍半富马酸盐 水合物

YM-202074 倍半富马酸盐水合物