产品说明
一般描述
HumanKine interleukin-23 (IL-23) is expressed as a heterodimeric 55 kDa cytokine composed of two glycosylated and disulfide linked subunits (p40 cystine linked to p19). Production in human HEK 293 cells offers authentic glycosylation. Cytokines produced in Sf9 or Sf21 cells have post-translational modifications, which are not human-like.
Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated dendritic cells and macrophages. It is a 20.7kDa protein with 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.
生化/生理作用
Interleukin-23 (IL-23) plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity, driving the expansion, stabilization and survival of Th17 cells.
分析说明
The specific activity was determined by the dose-dependent secretion of h-IFN-γ or IL-8 from human PBMC.
法律信息
HumanKine is a registered trademark of Proteintech Group, Inc.
基本信息
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 生物来源 | human |
| 重组 | expressed in HEK 293 cells |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | ≤2 ng/mL EC50 |
| 质量 | endotoxin tested |
| 分子量 | dimer 55 kDa (glycosylated) |
| 包装 | pkg of 5X10 μg pkg of 10 μg pkg of 5 μg |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | ≤1EU/mg |
| UniProt登记号 | Q9NPF7 |
| 储存温度 | −20℃ |
| Gene Information | human ... IL23A(51561) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
