产品说明
生化/生理作用
Oncostatin M (OSM), LIF, G-CSF, IL-6, and CNTF are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. OSM is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF β1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. OSM is secreted by macrophages and activated T lymphocytes.
外形
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
分析说明
The specific activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
法律信息
HumanKine is a registered trademark of Proteintech Group, Inc.
基本信息
| MDL编号 | MFCD00166731 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 生物来源 | human |
| 重组 | expressed in HEK 293 cells |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | ≤1 ng/mL EC50 |
| 质量 | endotoxin tested |
| 分子量 | dimer 30 kDa (glycosylated) |
| 包装 | pkg of 5X10 μg pkg of 10 μg |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | ≤1 EU/μg |
| UniProt登记号 | P13725 |
| 储存温度 | −20℃ |
| Gene Information | human ... OSM(5008) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
